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  • HOME
  • DOG BREEDS

    🐕 A - F

    • Australian Shepherd
    • Beagle
    • Boxer
    • Border Collie
    • Cocker Spaniel
    • Corgi
    • Dachshund
    • French Bulldog

    🐩 G - M

    • German Shepherd
    • German Shepherd Wolf
    • Goldendoodle
    • Greyhound
    • Havanese
    • Husky
    • Labradoodle
    • Maltese
    • Mastiff
    • Miniature Husky
    • Miniature Schnauzer
    • Morkie

    🐶 N - Z

    • Pitbull
    • Pomchi
    • Pomeranian
    • Pomsky
    • Poodle
    • Shih Tzu
    • Shorkie
    • Yorkie

    More Articles on Breeds

    Best Dog Food for Rhodesian Ridgebacks DogStruggles

    10 Best Dog Foods for Rhodesian Ridgebacks

    10 January 2022
    11 Smartest Small Dog Breeds Featured Image

    11 Smartest Small Dog Breeds

    10 January 2022

    Stages of Husky Puppy Development

    10 January 2022
    german shepherd belgian malinois featured on dogstruggles

    German Shepherd vs Belgian Malinois – Traits & Comparisons

    10 January 2022
    boxer beagle

    Beagle Boxer Mix – The Complete Boggle Dog Guide!

    10 January 2022
  • DOG FOOD
    • BY BREED
      • For American Bulldogs
      • For Australian Shepherds
      • For Basenjis
      • For Beagles
      • For Blue Heelers
      • For Border Collies
      • For Boxer Puppies
      • For Bull terriers
      • For Cavalier King Charles
      • For Chihuahua Puppies
      • For Cocker Spaniels
      • For Corgi Puppies
      • For Dachshunds
      • For Dalmations
      • For Dobermans
      • For French Bulldog Puppies
      • For German Shepherd Puppies
      • For German Shorthaired Pointers
      • For Golden Retrievers
      • For Great Danes
      • For Greyhounds
      • For Havanese
      • For Hunting Dogs
      • For Jack Russells
      • For Maltipoo
      • For Maltese Puppies
      • For Mastiffs
      • For Miniature Schnauzers
      • For Morkies
      • For Pomeranians  
      • For Poodles
      • For Husky Puppies
      • For Pitbulls
      • For Pugs
      • For Rhodesian Ridgebacks
      • For Rottweilers
      • For Shichons
      • For Saint Bernards
      • For Weimaraners
      • For Yorkies
    • COMPARISON
      • Annamaet
      • Bil-Jac
      • Canine Caviar
      • Evolve
      • Instinct
      • Brands on a Budget
      • Organic Brands
      • Nature’s Logic
      • Nulo
      • Orijen
      • Performatrin Ultra
      • Pro Pac
      • Royal Canin vs Blue Buffalo
      • Sojos
      • Taste of the Wild vs Blue Wilderness
      • Victor
      • Victor Dog Food vs Diamond Naturals
      • Weruva
      • Whole Earth Farm
    • FOR A PURPOSE
      • For Arthritis
      • For Bad Teeth
      • Dehydrated Dog Food
      • High-Calorie
      • High Fiber for Anal Gland Problems
      • Hypoallergenic Foods
      • For IBD 
      • Legume Free
      • Limited Ingredient Foods
      • Low Protein
      • Low Sodium
      • Ollie Dog Food Reviews
      • To Prevent Gas
      • Puppy Milk Replacer
      • For Picky Dogs
      • For Seizures
      • For Sensitive Stomachs
      • For Skin Allergies
      • For Yeast Infections
    • TREATS
      • Dentastix vs Greenies: Which is Better?
      • For Pomeranians
      • For Puppy Training
      • For Yorkies
  • DOG MEDICINE
    • Antihistamines for Allergies
    • Aspirin
    • Benadryl
    • Dewormers
    • DNA Tests
    • Dramamine
    • Ear Cleaners
    • Gabapentin
    • Glucosamine
    • Heartgard
    • Melatonin
    • Nexgard vs Frontline
    • Prednisone
    • Toothpastes
    • Tramadol
    • Trifexis vs Comfortis
    • Xanax
    • Zyrtec
  • DOG SUPPLIES
    • BEDS
      • Bedding for Kennels
      • Bedding for Puppies
      • Chew Proof beds
      • Elevated beds
      • For Australian Shepherds
      • For Beagles
      • For Bernese Mountain Dogs
      • For Border Collies
      • For Boston Terriers
      • For Boxers
      • For Bulldogs
      • For Chihuahuas
      • For Cockapoos
      • For Cocker Spaniels
      • For Corgis
      • For Coton De Tulears
      • For Dachshunds
      • For Dobermans
      • For English Mastiffs
      • For French Bulldogs
      • For German Shepherds
      • For Goldendoodles
      • For Great Danes
      • For Greyhounds
      • For Labradoodles
      • For Mastiffs
      • For Miniature Schnauzers
      • For Pitbulls
      • For Pomeranians
      • For Rhodesian Ridgebacks
      • For Rottweilers
      • For Shih Tzus
      • For Siberian Huskies
      • For Weimaraners
      • For Whippets
      • For Vizslas
      • For Yorkies
      • Heated Beds
      • Luxury Beds
      • Orthopedic Beds
      • Waterproof Beds
    • BRUSHES
      • For Australian Shepherds
      • For Boxer Dogs
      • For Corgis
      • For German Shepherds
      • For Goldendoodles
      • For Golden Retrievers
      • For Havanese
      • For Labradoodles
      • For Maltese
      • For Maltipoos
      • For Poodles
      • For Pitbulls
      • For Pomeranians
      • For Saint Bernards
      • For Shih Tzus
      • For Yorkies
    • COLLARS
      • Bark Collars
      • For Chihuahuas
      • Citronella Bark Collars
      • For Dobermans
      • For German Shepherds
      • Leather Collars
      • Reflective Collars
    • CLIPPERS
      • For Airedale Terriers
      • For Australian Shepherds
      • For Bichon Frise
      • For Border Collies
      • For Coton De Tulears
      • For German Shepherds
      • For Goldendoodles
      • For Havanese
      • For Labradoodles
      • For Lhasa Apso
      • For Maltese
      • For Matted Hair
      • For Miniature Schnauzers
      • For Old English Sheepdogs
      • For Pomeranians
      • For Poodles
      • For Portuguese Water Dogs
      • For Shih Tzus
    • CRATES
      • Crate Covers
      • For Beagles
      • For Border Collies
      • For Boston Terriers
      • For Boxers
      • For Cavalier King Charles Spaniels
      • For Chihuahuas
      • For Dachshunds
      • For Dobermans
      • For English Bulldogs
      • For Goldendoodles
      • For Golden Retrievers
      • For Great Danes
      • For Greyhounds
      • For Huskies
      • For Labradoodles
      • For Mastiffs
      • For Miniature Schnauzers
      • For Pitbulls
      • For Pomeranians
      • Revol Crate
      • For Rottweilers
      • For Separation Anxiety
      • For Shih Tzus
      • For Weimaraners
      • Crate Water Bottle
      • Wooden Dog Crates
      • For Yorkies
    • HARNESSES
      • For American Bulldogs
      • For Beagles
      • For Boxers
      • For Bulldogs
      • For Chihuahuas
      • For Dachshunds
      • For French Bulldogs
      • Freedom No Pull
      • For German Shepherds
      • For Golden Retrievers
      • K9 Harness
      • For Pugs
      • For Rottweilers
      • For Shih Tzu
      • For Siberian Husky
      • For Yorkies
    • LEASHES
      • For Pitbulls
      • For Running
      • Retractable
    • MUZZLES
      • Basket Muzzles
      • For Chihuahuas
      • For Pitbulls
    • NAIL CLIPPERS
      • For Cockapoos
      • For Golden Retrievers
    • TOYS
      • Balls
      • Chew Toys for Pit Bulls
      • For Border Collies
      • For Corgis
      • For Dalmations
      • Frisbees
      • Interactive Toys
      • Playpens
      • For Pomeranians
      • Pools
      • Puppy Chew Toys
      • For Shih Tzus
      • Squeaky Toys
      • Tug Toys
    • SHAMPOO
      • For Bulldogs
      • Flea Shampoos
      • For French Bulldogs
      • For Goldendoodles
      • For Golden Retrievers
      • For Huskies
      • Hypoallergenic Shampoos
      • For Maltese
      • Natural Shampoos for Sensitive Skin
      • Oatmeal Shampoos
      • For Pitbulls
      • For Pomeranians
      • For Poodles
      • For Puppies
      • For Shih Tzu
      • For Yorkies
    • Boston Terrier Sweater
    • Dog Camping Tents
    • Hunting Vests
    • Flea Carpet Powder
    • Strollers
    • Training Books
    • Pet Hair Vacuums
  • BLOG
    • Can My Dog Eat That?
      • Biscuits
      • Cheerios
      • Chia Seeds
      • Cinnamon
      • Crackers
      • Dairy
        • Cheese
        • Vanilla Ice Cream
      • Eggs
      • Falafel
      • Fruit
        • Apples
        • Avocado
        • Bananas
        • Blackberries
        • Coconut
        • Mangoes
        • Strawberries
        • Tomatoes
        • Zucchini
      • Honey
      • Hot Sauce
      • Instant Noodles
      • Meat
        • Chicken Bones
        • Chicken Skin
        • Ham Bones
        • Salami
        • Sausage
        • Steak
        • Trout
        • Tuna
        • Turkey
      • Oatmeal
      • Peanut Butter
      • Pink Salt
      • Pita Bread
      • Pizza Crust
      • Popcorn
      • Potato
      • Sunflower Seeds
      • Vegetables
        • Beans
        • Brussel Sprouts
        • Carrots
        • Green Peppers
        • Lettuce
        • Onions
        • Truffles
        • Yellow Squash
    • Cats vs. Dogs
    • Exotic Dog Breeds
      • African
      • Chinese
      • Cleanest
      • Curly Haired
      • English
      • Fastest
      • Long-Legged
      • Small White
      • Smartest Small Breeds
    • Guides
      • Benefits and Risks of a Raw Diet
      • Can I Give My Dog Aspirin?
      • Does CBD Work for Dogs? 
      • Dogs Insurance Will Not Cover
      • Fixing Your Dogs Fear of Bathing
      • Guide to Crate Training a Puppy
      • Guide To Dog Digestion
      • How Long Does It Take To Groom a Dog?
      • How Often Can I Bathe My Dog With Flea Shampoo
      • How Often Should You Wash Your Dog?
      • Why Do Dogs Eat Cat Poop?
      • Why Does My Dog Pee On My Bed?
    • GPS Chips
    • How To Guides
      • Keep Dog Off Bed
      • Leash Train a Dog That Won’t Walk
      • Make a Leash Out of Paracord
      • Make a Leather Collar
      • Measure a Dog For a Muzzle
      • Put a Dog Tag on a Collar
      • Sedate a Dog for Grooming
      • Sharpen Nail Clippers
      • Stop Dog from Digging
      • Store Dry Dog Food Long Term
      • Train Dog for Protection
      • Train Dog to Sit Down
      • Wash a Dog Bed With Stuffing
    • Superpowers Dogs Have
    • Why Do Dogs
      • Cough
      • Eat Grass
      • Eat Socks
      • Hump The Air
      • Keep Licking Their Paws
      • Look Sad
      • Penises Stay Out
      • Put Their Ears Back
      • Sleep So Much
      • Wag their Tail
      • Watch TV
    • Why Walking Your Dog is Good for You
  • ABOUT US
  • HOME
  • DOG BREEDS

    🐕 A - F

    • Australian Shepherd
    • Beagle
    • Boxer
    • Border Collie
    • Cocker Spaniel
    • Corgi
    • Dachshund
    • French Bulldog

    🐩 G - M

    • German Shepherd
    • German Shepherd Wolf
    • Goldendoodle
    • Greyhound
    • Havanese
    • Husky
    • Labradoodle
    • Maltese
    • Mastiff
    • Miniature Husky
    • Miniature Schnauzer
    • Morkie

    🐶 N - Z

    • Pitbull
    • Pomchi
    • Pomeranian
    • Pomsky
    • Poodle
    • Shih Tzu
    • Shorkie
    • Yorkie

    More Articles on Breeds

    Best Dog Food for Rhodesian Ridgebacks DogStruggles

    10 Best Dog Foods for Rhodesian Ridgebacks

    10 January 2022
    11 Smartest Small Dog Breeds Featured Image

    11 Smartest Small Dog Breeds

    10 January 2022

    Stages of Husky Puppy Development

    10 January 2022
    german shepherd belgian malinois featured on dogstruggles

    German Shepherd vs Belgian Malinois – Traits & Comparisons

    10 January 2022
    boxer beagle

    Beagle Boxer Mix – The Complete Boggle Dog Guide!

    10 January 2022
  • DOG FOOD
    • BY BREED
      • For American Bulldogs
      • For Australian Shepherds
      • For Basenjis
      • For Beagles
      • For Blue Heelers
      • For Border Collies
      • For Boxer Puppies
      • For Bull terriers
      • For Cavalier King Charles
      • For Chihuahua Puppies
      • For Cocker Spaniels
      • For Corgi Puppies
      • For Dachshunds
      • For Dalmations
      • For Dobermans
      • For French Bulldog Puppies
      • For German Shepherd Puppies
      • For German Shorthaired Pointers
      • For Golden Retrievers
      • For Great Danes
      • For Greyhounds
      • For Havanese
      • For Hunting Dogs
      • For Jack Russells
      • For Maltipoo
      • For Maltese Puppies
      • For Mastiffs
      • For Miniature Schnauzers
      • For Morkies
      • For Pomeranians  
      • For Poodles
      • For Husky Puppies
      • For Pitbulls
      • For Pugs
      • For Rhodesian Ridgebacks
      • For Rottweilers
      • For Shichons
      • For Saint Bernards
      • For Weimaraners
      • For Yorkies
    • COMPARISON
      • Annamaet
      • Bil-Jac
      • Canine Caviar
      • Evolve
      • Instinct
      • Brands on a Budget
      • Organic Brands
      • Nature’s Logic
      • Nulo
      • Orijen
      • Performatrin Ultra
      • Pro Pac
      • Royal Canin vs Blue Buffalo
      • Sojos
      • Taste of the Wild vs Blue Wilderness
      • Victor
      • Victor Dog Food vs Diamond Naturals
      • Weruva
      • Whole Earth Farm
    • FOR A PURPOSE
      • For Arthritis
      • For Bad Teeth
      • Dehydrated Dog Food
      • High-Calorie
      • High Fiber for Anal Gland Problems
      • Hypoallergenic Foods
      • For IBD 
      • Legume Free
      • Limited Ingredient Foods
      • Low Protein
      • Low Sodium
      • Ollie Dog Food Reviews
      • To Prevent Gas
      • Puppy Milk Replacer
      • For Picky Dogs
      • For Seizures
      • For Sensitive Stomachs
      • For Skin Allergies
      • For Yeast Infections
    • TREATS
      • Dentastix vs Greenies: Which is Better?
      • For Pomeranians
      • For Puppy Training
      • For Yorkies
  • DOG MEDICINE
    • Antihistamines for Allergies
    • Aspirin
    • Benadryl
    • Dewormers
    • DNA Tests
    • Dramamine
    • Ear Cleaners
    • Gabapentin
    • Glucosamine
    • Heartgard
    • Melatonin
    • Nexgard vs Frontline
    • Prednisone
    • Toothpastes
    • Tramadol
    • Trifexis vs Comfortis
    • Xanax
    • Zyrtec
  • DOG SUPPLIES
    • BEDS
      • Bedding for Kennels
      • Bedding for Puppies
      • Chew Proof beds
      • Elevated beds
      • For Australian Shepherds
      • For Beagles
      • For Bernese Mountain Dogs
      • For Border Collies
      • For Boston Terriers
      • For Boxers
      • For Bulldogs
      • For Chihuahuas
      • For Cockapoos
      • For Cocker Spaniels
      • For Corgis
      • For Coton De Tulears
      • For Dachshunds
      • For Dobermans
      • For English Mastiffs
      • For French Bulldogs
      • For German Shepherds
      • For Goldendoodles
      • For Great Danes
      • For Greyhounds
      • For Labradoodles
      • For Mastiffs
      • For Miniature Schnauzers
      • For Pitbulls
      • For Pomeranians
      • For Rhodesian Ridgebacks
      • For Rottweilers
      • For Shih Tzus
      • For Siberian Huskies
      • For Weimaraners
      • For Whippets
      • For Vizslas
      • For Yorkies
      • Heated Beds
      • Luxury Beds
      • Orthopedic Beds
      • Waterproof Beds
    • BRUSHES
      • For Australian Shepherds
      • For Boxer Dogs
      • For Corgis
      • For German Shepherds
      • For Goldendoodles
      • For Golden Retrievers
      • For Havanese
      • For Labradoodles
      • For Maltese
      • For Maltipoos
      • For Poodles
      • For Pitbulls
      • For Pomeranians
      • For Saint Bernards
      • For Shih Tzus
      • For Yorkies
    • COLLARS
      • Bark Collars
      • For Chihuahuas
      • Citronella Bark Collars
      • For Dobermans
      • For German Shepherds
      • Leather Collars
      • Reflective Collars
    • CLIPPERS
      • For Airedale Terriers
      • For Australian Shepherds
      • For Bichon Frise
      • For Border Collies
      • For Coton De Tulears
      • For German Shepherds
      • For Goldendoodles
      • For Havanese
      • For Labradoodles
      • For Lhasa Apso
      • For Maltese
      • For Matted Hair
      • For Miniature Schnauzers
      • For Old English Sheepdogs
      • For Pomeranians
      • For Poodles
      • For Portuguese Water Dogs
      • For Shih Tzus
    • CRATES
      • Crate Covers
      • For Beagles
      • For Border Collies
      • For Boston Terriers
      • For Boxers
      • For Cavalier King Charles Spaniels
      • For Chihuahuas
      • For Dachshunds
      • For Dobermans
      • For English Bulldogs
      • For Goldendoodles
      • For Golden Retrievers
      • For Great Danes
      • For Greyhounds
      • For Huskies
      • For Labradoodles
      • For Mastiffs
      • For Miniature Schnauzers
      • For Pitbulls
      • For Pomeranians
      • Revol Crate
      • For Rottweilers
      • For Separation Anxiety
      • For Shih Tzus
      • For Weimaraners
      • Crate Water Bottle
      • Wooden Dog Crates
      • For Yorkies
    • HARNESSES
      • For American Bulldogs
      • For Beagles
      • For Boxers
      • For Bulldogs
      • For Chihuahuas
      • For Dachshunds
      • For French Bulldogs
      • Freedom No Pull
      • For German Shepherds
      • For Golden Retrievers
      • K9 Harness
      • For Pugs
      • For Rottweilers
      • For Shih Tzu
      • For Siberian Husky
      • For Yorkies
    • LEASHES
      • For Pitbulls
      • For Running
      • Retractable
    • MUZZLES
      • Basket Muzzles
      • For Chihuahuas
      • For Pitbulls
    • NAIL CLIPPERS
      • For Cockapoos
      • For Golden Retrievers
    • TOYS
      • Balls
      • Chew Toys for Pit Bulls
      • For Border Collies
      • For Corgis
      • For Dalmations
      • Frisbees
      • Interactive Toys
      • Playpens
      • For Pomeranians
      • Pools
      • Puppy Chew Toys
      • For Shih Tzus
      • Squeaky Toys
      • Tug Toys
    • SHAMPOO
      • For Bulldogs
      • Flea Shampoos
      • For French Bulldogs
      • For Goldendoodles
      • For Golden Retrievers
      • For Huskies
      • Hypoallergenic Shampoos
      • For Maltese
      • Natural Shampoos for Sensitive Skin
      • Oatmeal Shampoos
      • For Pitbulls
      • For Pomeranians
      • For Poodles
      • For Puppies
      • For Shih Tzu
      • For Yorkies
    • Boston Terrier Sweater
    • Dog Camping Tents
    • Hunting Vests
    • Flea Carpet Powder
    • Strollers
    • Training Books
    • Pet Hair Vacuums
  • BLOG
    • Can My Dog Eat That?
      • Biscuits
      • Cheerios
      • Chia Seeds
      • Cinnamon
      • Crackers
      • Dairy
        • Cheese
        • Vanilla Ice Cream
      • Eggs
      • Falafel
      • Fruit
        • Apples
        • Avocado
        • Bananas
        • Blackberries
        • Coconut
        • Mangoes
        • Strawberries
        • Tomatoes
        • Zucchini
      • Honey
      • Hot Sauce
      • Instant Noodles
      • Meat
        • Chicken Bones
        • Chicken Skin
        • Ham Bones
        • Salami
        • Sausage
        • Steak
        • Trout
        • Tuna
        • Turkey
      • Oatmeal
      • Peanut Butter
      • Pink Salt
      • Pita Bread
      • Pizza Crust
      • Popcorn
      • Potato
      • Sunflower Seeds
      • Vegetables
        • Beans
        • Brussel Sprouts
        • Carrots
        • Green Peppers
        • Lettuce
        • Onions
        • Truffles
        • Yellow Squash
    • Cats vs. Dogs
    • Exotic Dog Breeds
      • African
      • Chinese
      • Cleanest
      • Curly Haired
      • English
      • Fastest
      • Long-Legged
      • Small White
      • Smartest Small Breeds
    • Guides
      • Benefits and Risks of a Raw Diet
      • Can I Give My Dog Aspirin?
      • Does CBD Work for Dogs? 
      • Dogs Insurance Will Not Cover
      • Fixing Your Dogs Fear of Bathing
      • Guide to Crate Training a Puppy
      • Guide To Dog Digestion
      • How Long Does It Take To Groom a Dog?
      • How Often Can I Bathe My Dog With Flea Shampoo
      • How Often Should You Wash Your Dog?
      • Why Do Dogs Eat Cat Poop?
      • Why Does My Dog Pee On My Bed?
    • GPS Chips
    • How To Guides
      • Keep Dog Off Bed
      • Leash Train a Dog That Won’t Walk
      • Make a Leash Out of Paracord
      • Make a Leather Collar
      • Measure a Dog For a Muzzle
      • Put a Dog Tag on a Collar
      • Sedate a Dog for Grooming
      • Sharpen Nail Clippers
      • Stop Dog from Digging
      • Store Dry Dog Food Long Term
      • Train Dog for Protection
      • Train Dog to Sit Down
      • Wash a Dog Bed With Stuffing
    • Superpowers Dogs Have
    • Why Do Dogs
      • Cough
      • Eat Grass
      • Eat Socks
      • Hump The Air
      • Keep Licking Their Paws
      • Look Sad
      • Penises Stay Out
      • Put Their Ears Back
      • Sleep So Much
      • Wag their Tail
      • Watch TV
    • Why Walking Your Dog is Good for You
  • ABOUT US
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Dog struggles
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Home Dog medicine

Benadryl For Dogs – Is it Safe?

Sarah Robinson by Sarah Robinson
8 January 2022
in Dog medicine
benadryl for dogs featured on dogstruggles
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Is your dog itchy or does he suffer from motion sickness?

If the answer is “Yes”, then it may have occurred to you to try Benadryl in order to settle his symptoms.

Benadryl is a popular antihistamine for people, which is widely available without a prescription.

However, when giving dogs Benadryl you need to be aware of a few simple does and don’ts in order to avoid some potentially dangerous complications.

1. What is Benadryl?

Let’s start at the beginning by looking at what Benadryl is and when you can consider Benadryl for dogs.

Benadryl is the trading name for a group of products that contain antihistamines.

And this is where the first warning pops up.

For many years the Benadryl brand contained the active ingredient diphenhydramine.

This drug is safe for the majority of dogs (although there are some dogs who shouldn’t take it) and has some interesting properties such as alleviating itchiness, reducing motion sickness, and soothing coughs.

However, recently new drugs have crept into the Benadryl product range, for example, cetirizine (an antihistamine), acrivastine, and pseudoephedrine (a decongestant).

Whilst cetirizine is safe for most dogs, it is purely an anti-allergy product and has no effect on coughs or motion sickness.

black image dog watching

Also, there is not enough data to know if acrivastine is safe for dogs and so is best avoided.

But most important of all is to know that pseudoephedrine is potentially toxic to dogs.

This means that a Benadryl product that says “decongestant” on the label is likely to contain pseudoephedrine and is therefore NOT safe for dogs.

Thus when wondering “Is Benadryl safe for dogs?” – The answer, yes and no, it depends on the active ingredients.

2. Follow the rules

When you pick up a Benadryl packet, always read the active ingredients!

  • Greenlight to go ahead:
  • Diphenhydramine
  • Cetirizine
  • Red light to stop:
  • Pseudoephedrine
  • Acrivastine

Of course, always check with your veterinarian first before giving any new medication, because safe for a healthy dog, may not mean safe for a dog with an underlying health problem or that is already on medication.

For example, do NOT give any Benadryl product if your dog has the following:

  • High blood pressure
  • Glaucoma
  • Urinary problems (including incontinence)
  • Overactive thyroid glands
  • Take an MAO inhibitor medication such as isocarboxazid, phenelzine, or tranylcypromine

All of the above can have potentially serious interactions with Benadryl products or other antihistamines and mixing the two is not advisable.

3. What is an Antihistamine and How Do They Work?

Diphenhydramine and cetirizine both belong to a group of drugs called antihistamines.

They were developed to alleviate the signs associated with allergies in people such as hay fever, with its associated sneezing, hot itchy eyes, and a runny nose.

It just so happens that some antihistamines have other actions such as relieving nausea associated with travel sickness and reducing the urge to cough.

Unfortunately in dogs, the effect of antihistamines can be disappointing.

dog sitting and watching

They can work well in some dogs, but in others, they either have a reduced effect or are of no benefit at all.

Sadly, it is impossible to predict if Benadryl will help your dog and the only way to know is to try it and see. (Provided it is safe to do so).

Antihistamines work by counteracting a substance in the body called histamine.

This is released from mast cells as part of the body’s immune response when it detects foreign substances called allergens.

You will be most familiar with allergens such as the pollens which cause hay fever in humans.

In some cases, the body gets carried away and produces an excessive amount of histamine which then leads to inflammation, irritation, and itchiness.

By canceling out the extra histamine, antihistamines calm this allergic reaction.

Dogs also experience allergic reactions to substances in the environment, and this condition is known as atopy.

Rather than sore eyes and a runny nose, this more typically shows itself as itchy skin, with the dog obsessively licking or chewing his feet.

However, as already mentioned, the response to antihistamines can be disappointing in some dogs and it’s a case of trying it to see what happens.

4. Dogs and Benadryl

So when might Benadryl be useful to give to your dog?

Consider using Benadryl product containing diphenhydramine in the following circumstances:

  • The dog is otherwise healthy and not on other medications
  • Has an allergic itch
  • Has a cough
  • Suffers from motion sickness

Consider using a Benadryl product containing cetirizine in the following circumstances:

  • The dog is otherwise healthy and not on other medications
  • Has an allergic itch

5. What is the Benadryl Dosage for Dogs?

First, take a look at the Benadryl packaging to discover what the active ingredient is and confirm there is no pseudoephedrine or acrivastine present!

A) Active ingredient: Cetirizine

This is commonly found in the ‘one a day’ or ’24 hour action’ allergy relief formulations.

Bear in mind this is purely for allergy symptoms, and will not benefit the coughing dog or one that suffers from motion sickness.

yellow to brown puppy sleep

The Benadryl dosage dogs take is 1 – 2 mg/kg body weight once a day.

This means a 10 kg dog needs 10mg once a day, which is equivalent to a single Benadryl Allergy Liquid Release capsule.

This is given with our without food but it’s best to wash it down with a drink of water.

B) Active ingredient: Diphenhydramine

The Benadryl dose for dogs that are itchy is 1 – 2 mg/kg body weight, two or three times daily.

This is equivalent to a 10kg dog taking half a Benadryl Allergy 25 mg tablet.

Usually, a maximum dose of 25 – 50mg is given, even to giant dogs.

When working out how much Benadryl for a dog with motion sickness or a cough, it is slightly higher at 2 – 4 mg/kg body weight, given two or three times daily.

This works out at about one to one-and-a-half Benadryl Allergy 25 mg tablets for a 10 kg dog, with a ceiling dose of 50mg for even the largest dog.

Be aware the diphenhydramine does have a sedative effect on some dogs.

dogs together sleeping

This may be a hidden blessing for the dog with kennel cough that can’t sleep at night.

However, if you are using Benadryl to relieve travel sickness, it might be not such a good choice if you want the dog to be lively at the other end of the journey.

For example, if your dog gets sick on the car ride to the dog park, then giving Benadryl may make him too sleepy to play when you get there.

If however you are moving house and it would be helpful that Fido isn’t bouncing off the walls when you arrive at your new pad, then being sleepy can be a bonus.

Bottom Line

Just to further complicate things, you will find the active ingredients in Benadryl products vary between countries.

Whilst the US Benadryl contains mainly diphenhydramine, this is not the case in the UK.

If you happen to have a product obtained from the UK, check the packaging carefully since most contain acrivastine.

At the present time there is little data about this newer drug, acrivastine, and how it affects dogs.

With this in mind, it is not safe to give to dogs.

dog adult sad

For those living in the UK, alternative products containing diphenhydramine include Nytol, Sleep-eze, and Siladryl (always check the label before administering).

Indeed, it’s important to be aware that none of the products mentioned in this article are licensed for use in dogs by the FDA.

As such you are therefore using them ‘off label’ and at your own risk.

Always be cautious when giving any medication to a pet and it’s always best to check in with your vet first to check it is safe to do so.

Best of luck and here’s hoping for a relaxed, itch-free pet this summer pollen season! Read our comprehensive guide on https://dogstruggles.com/medication/.

Sarah Robinson

Sarah Robinson

Dr Sarah Robinson attended veterinary school at Oklahoma State University receiving a D.V.M. in 2008. Sarah’s longtime interest is to help people to better communicate with their pet companions, and in doing so, to help them to strengthen their relationships with their dogs and cats. Sarah has published numerous articles on canine feeding in pet related magazines, veterinary journals and leading natural health web sites.

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